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KMID : 1144820190250020131
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대한의생명과학회지
2019 Volume.25 No. 2 p.131 ~ p.138
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Effects of Sea Buckthorn and Boswellia Extracts in Inflammatory Orofacial Pain by Xerostomia in Rats
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Choi Ja-Hyeong
Kim Tae-Heon
Lee Min-Kyung
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Abstract
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Xerostomia due to the subjective dry mouth feeling that may occur even when the salivary gland function reduction is not objectively confirmed. The purpose of this study was to investigate whether or not dry mouth is more sensitive to pain in the oral facial area, which is the main cause of dental problems. The natural products used in this study are Boswellia serrata and seabuckthorn, Both natural substances are known as a representative antioxidant substance rich in vitamins. 4-DAMP was injected into the peritoneal cavity of the experimental animals, and 5% formalin was injected into the face to observe the change of inflammatory pain. Boswellia (15, 30 mg/kg) or seabuckthorn (150, 30 mg/kg, 5 mg/kg) after formalin infusion, As a result, pain response was significantly reduced in the drug-infused group compared to the formalin-infused group (*P<0.05). It was also found that the two drugs were more effective when administered together. Based on these results, we confirm that natural extract can be an alternative treatment modality for the control of oral facial inflammatory pain.
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KEYWORD
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Xerostomia, Boswellia serrata, Sea buckthorn, Orofacial pain
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